Treatment of growth plate injury using IGF-I-loaded PLGA scaffolds.

  title={Treatment of growth plate injury using IGF-I-loaded PLGA scaffolds.},
  author={Sharath Kumar C Sundararaj and Ryan D Cieply and Gautam Gupta and Todd A Milbrandt and David A. Puleo},
  journal={Journal of tissue engineering and regenerative medicine},
  volume={9 12},
Growth plate fracture can lead to retarded growth and unequal limb length, which may have a lifelong effect on a person's physical stature. The goal of this research was to develop an in vivo tissue-engineering approach for the treatment of growth plate injury via localized delivery of insulin-like growth factor I (IGF-I) from cell-free poly(lactic-co-glycolic acid) (PLGA) scaffolds. Mass loss and drug release studies were conducted to study the scaffold degradation and IGF-I release patterns… CONTINUE READING
4 Citations
37 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 37 references

Similar Papers

Loading similar papers…