Treatment of growth plate injury using IGF-I-loaded PLGA scaffolds.

@article{Sundararaj2015TreatmentOG,
  title={Treatment of growth plate injury using IGF-I-loaded PLGA scaffolds.},
  author={Sharath Kumar C Sundararaj and Ryan D Cieply and Gautam Gupta and Todd A Milbrandt and David A. Puleo},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2015},
  volume={9 12},
  pages={E202-9}
}
Growth plate fracture can lead to retarded growth and unequal limb length, which may have a lifelong effect on a person's physical stature. The goal of this research was to develop an in vivo tissue-engineering approach for the treatment of growth plate injury via localized delivery of insulin-like growth factor I (IGF-I) from cell-free poly(lactic-co-glycolic acid) (PLGA) scaffolds. Mass loss and drug release studies were conducted to study the scaffold degradation and IGF-I release patterns… CONTINUE READING
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