Treatment of granulomatous amoebic encephalitis with voriconazole and miltefosine in an immunocompetent soldier.

@article{Webster2012TreatmentOG,
  title={Treatment of granulomatous amoebic encephalitis with voriconazole and miltefosine in an immunocompetent soldier.},
  author={Duncan Webster and Imran Umar and George N Kolyvas and Juan Bilbao and M Guiot and Kevin Duplisea and Yvonne Qvarnstrom and Govinda S. Visvesvara},
  journal={The American journal of tropical medicine and hygiene},
  year={2012},
  volume={87 4},
  pages={715-8}
}
A 38-year-old male immunocompetent soldier developed generalized seizures. He underwent surgical debulking and a progressive demyelinating pseudotumor was identified. Serology and molecular testing confirmed a diagnosis of granulomatous amoebic encephalitis caused by Acanthamoeba sp. in this immunocompetent male. The patient was treated with oral voriconazole and miltefosine with Acanthamoeba titers returning to control levels and serial imaging demonstrating resolution of the residual lesion.