Treatment of gastrointestinal stromal tumor: focus on imatinib mesylate

@article{Din2008TreatmentOG,
  title={Treatment of gastrointestinal stromal tumor: focus on imatinib mesylate},
  author={Omar Sadeeq Din and Penella Woll},
  journal={Therapeutics and Clinical Risk Management},
  year={2008},
  volume={4},
  pages={149 - 162}
}
Gastrointestinal stromal tumor (GIST) is a rare primary neoplasm of the gastrointestinal tract, mesentery, or omentum. In the past, surgery has been the only effective treatment. The diagnosis and treatment of GIST has been revolutionized over the past decade, since expression of the receptor tyrosine kinase KIT was shown to occur on these tumors. Mutations in this proto-oncogene commonly cause constitutive activation of the KIT tyrosine kinase receptor, an important factor in the pathogenesis… CONTINUE READING
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