Treatment of experimental visceral leishmaniasis with amphotericin B in stable albumin microspheres.

@article{SanchezBrunete2004TreatmentOE,
  title={Treatment of experimental visceral leishmaniasis with amphotericin B in stable albumin microspheres.},
  author={J. A. Sanchez-Brunete and Mar{\'i}a A Dea and Sreedhar Rama and Francisco Bol{\'a}s and Jos{\'e} M Alunda and Rafaela Raposo and Maria Teresa M{\'e}ndez and Santiago Torrado-Santiago and Juan Jos{\'e} Torrado},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 9},
  pages={3246-52}
}
Hydrophilic albumin microspheres are proposed as a new delivery system for amphotericin B (AMB; AMB microspheres). The acute toxicity of AMB microspheres was lower than that of the AMB-deoxycholate (AMB-Doc) reference formulation in hamsters. Lethal doses in healthy and infected animals were improved at least eight times. Intravenous bolus administration of doses of AMB microspheres up to 40 mg/kg of body weight did not produce acute symptoms of toxicity. The efficacy of this new formulation… CONTINUE READING

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