Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone

  title={Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone},
  author={Y. Duchossoy and S. David and E. Baulieu and P. Robel},
  journal={Brain Research},
  • Y. Duchossoy, S. David, +1 author P. Robel
  • Published 2011
  • Medicine
  • Brain Research
  • The synthetic derivative of pregnenolone MAP4343 (3β-methoxy-pregnenolone) binds in vitro to microtubule-associated-protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents. Its efficacy was assessed in vivo with the most commonly used thoracic spinal cord compression/contusion models in rats. In the three models used, the post-traumatic subcutaneous injection of MAP4343 significantly improved the recovery of… CONTINUE READING
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