• DOI:10.1016/j.brainres.2011.05.065
Corpus ID: 42657539

Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone

@article{Duchossoy2011TreatmentOE,
  title={Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone},
  author={Y. Duchossoy and S. David and E. Baulieu and P. Robel},
  journal={Brain Research},
  year={2011},
  volume={1403},
  pages={57-66}
}

Y. Duchossoy, S. David, +1 author P. Robel

Published 2011

Medicine

Brain Research

The synthetic derivative of pregnenolone MAP4343 (3β-methoxy-pregnenolone) binds in vitro to microtubule-associated-protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents. Its efficacy was assessed in vivo with the most commonly used thoracic spinal cord compression/contusion models in rats. In the three models used, the post-traumatic subcutaneous injection of MAP4343 significantly improved the recovery of… CONTINUE READING

View on Elsevier

mapreg.com

Save to Library

Create Alert

Cite

Launch Research Feed