Treatment of experimental pneumonia in rats caused by a PER-1 extended-spectrum beta-lactamase-producing strain of Pseudomonas aeruginosa.

@article{Mimoz1999TreatmentOE,
  title={Treatment of experimental pneumonia in rats caused by a PER-1 extended-spectrum beta-lactamase-producing strain of Pseudomonas aeruginosa.},
  author={Olivier Mimoz and N Elhelali and Sophie L{\'e}otard and Anne Jacolot and Fr{\'e}d{\'e}ric Laurent and Kamran Samii and Olivier Petitjean and Patrice L. Nordmann},
  journal={The Journal of antimicrobial chemotherapy},
  year={1999},
  volume={44 1},
  pages={91-7}
}
The antibacterial activity of imipenem, cefepime and piperacillin-tazobactam alone or in combination with amikacin against a Pseudomonas aeruginosa strain producing an extended-spectrum beta-lactamase (PER-1) were compared using an experimental model of pneumonia in non-leucopenic rats. Animals were infected intratracheally with 8.0 +/- 0.4 log10 cfu of P. aeruginosa, and therapy was initiated 3 h later, by which time animal lungs showed bilateral pneumonia containing >7 log10 P. aeruginosa cfu… CONTINUE READING