Treatment of experimental injury of anal sphincters with primary surgical repair and injection of bone marrow-derived mesenchymal stem cells.

@article{Lorenzi2008TreatmentOE,
  title={Treatment of experimental injury of anal sphincters with primary surgical repair and injection of bone marrow-derived mesenchymal stem cells.},
  author={Bruno Lorenzi and Federica Pessina and Paola Lorenzoni and Serena Urbani and Remo Vernillo and Giampietro Sgaragli and Renato Gerli and Benedetta Mazzanti and Alberto Bosi and Riccardo Saccardi and Marco Lorenzi},
  journal={Diseases of the colon and rectum},
  year={2008},
  volume={51 4},
  pages={411-20}
}
PURPOSE Sphincter injury is a common cause of anal incontinence. Surgical repair remains the operation of choice; however, the outcome often is poor. We investigated the ability of injected bone marrow-derived mesenchymal stem cells to enhance sphincter healing after injury and primary repair in a preclinical model. METHODS Twenty-four inbred Wistar Furth rats were divided into three groups. As a control, Group A underwent sham operation. Group B had sphincterotomy and repair of both anal… CONTINUE READING

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