Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine.

@article{Tarkowski1999TreatmentOE,
  title={Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine.},
  author={Andrej Tarkowski and Jixiong Sun and Rikard Holmdahl and BarbaraJ. Stoll Jan Holmgren and C{\'e}cil Czerkinsky},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 8},
  pages={
          1628-34
        }
}
OBJECTIVE To assess the efficacy of intranasal administration of microgram amounts of type II collagen (CII) coupled to cholera toxin B subunit (CTB) with respect to the development of collagen-induced arthritis, even when given after the onset of clinically evident arthropathy. METHODS DBA/1 mice were immunized with CII to induce arthritis and were subsequently treated with CTB-CII, CTB-conjugated ovalbumin, or CII alone. The incidence and severity of arthritis were assessed clinically and… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Similar Papers

Loading similar papers…