Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate.

@article{Higaki2005TreatmentOE,
  title={Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate.},
  author={Megumu Higaki and Tsutomu Ishihara and Nobuo Izumo and Miwa Takatsu and Yutaka Mizushima},
  journal={Annals of the rheumatic diseases},
  year={2005},
  volume={64 8},
  pages={1132-6}
}
OBJECTIVE To examine the therapeutic activity of hydrophilic glucocorticoid encapsulated in PLGA nanoparticles, which have shown slow release and are targeted to inflamed joints after intravenous administration, in experimental arthritis models. METHODS Betamethasone sodium phosphate (BSP) encapsulated in PLGA nanoparticles with a size of 100-200 nm (PLGA-nanosteroid) was prepared using a modified oil in water emulsion solvent diffusion method with Zn ions and coated with lecithin. Rats with… CONTINUE READING
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