Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85.

@article{Tselios2000TreatmentOE,
  title={Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85.},
  author={Theodore V. Tselios and Ioanna Daliani and Spyros N. Deraos and Sotiria Thymianou and Elizabeth Matsoukas and Anastassios Troganis and Ioannis P. Gerothanassis and Athanasia Mouzaki and Thomas M. Mavromoustakos and Lesley Probert and John M. Matsoukas},
  journal={Bioorganic & medicinal chemistry letters},
  year={2000},
  volume={10 24},
  pages={2713-7}
}
In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP(72-85) are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Ala81MBP(72-85). The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with… CONTINUE READING

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