Three hundred seventy-nine consecutive patients with adenocarcinoma of the corpus uteri, in whom irradiation was part of the treatment, were reviewed. The minimum follow-up was 3 years and none were lost. An increased incidence of corpus cancer in Central New York was demonstrated but could not be attributed to estrogen usage. There were 310 patients in FIGO stage I and 40 in stage II. Adenocarcinoma was reported in 319 and adenoacanthoma in 45. Overall survival was 74% and 62% at 5 and 10 years, respectively, and in stage I, 82% and 68%, respectively. Results for adenoacanthoma were similar to those for adenocarcinoma. Ten year survival was significantly better in those patients with a histologically negative hysterectomy specimen after preoperative intracavitary irradiation than in those with residual cancer. Treatment was tolerated well. This study demonstrates the results which can be obtained in a regional radiation therapy center serving patients and gynecologists from a wide geographic region operated upon in many different hospitals.