Treatment of elevated intracranial pressure in experimental intracerebral hemorrhage: comparison between mannitol and hypertonic saline.

@article{Qureshi1999TreatmentOE,
  title={Treatment of elevated intracranial pressure in experimental intracerebral hemorrhage: comparison between mannitol and hypertonic saline.},
  author={A I Qureshi and David A. H. Wilson and Richard J. Traystman},
  journal={Neurosurgery},
  year={1999},
  volume={44 5},
  pages={1055-63; discussion 1063-4}
}
OBJECTIVE Elevated intracranial pressure (ICP) is related to mortality after intracerebral hemorrhage (ICH). To develop effective strategies for the medical treatment of ICP in cases of ICH, we evaluated the therapeutic efficacy of mannitol and hypertonic saline in a canine model of ICH. METHODS We introduced ICH in three groups of anesthetized mongrel dogs, consisting of seven animals each, by autologous blood injection (5.5-7.5 ml) under arterial pressure in the deep white matter adjacent… CONTINUE READING

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