Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.

  title={Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.},
  author={Stefan Rutkowski and Udo Bode and Frank Deinlein and Holger Ottensmeier and Monika Warmuth-Metz and Niels Soerensen and Norbert Graf and Angela Emser and Torsten Pietsch and Johannes E. A. Wolff and Rolf Dieter Kortmann and Joachim Kuehl},
  journal={The New England journal of medicine},
  volume={352 10},
BACKGROUND The prognosis for young children with medulloblastoma is poor, and survivors are at high risk for cognitive deficits. We conducted a trial of the treatment of this brain tumor by intensive postoperative chemotherapy alone. METHODS After surgery, children received three cycles of intravenous chemotherapy (cyclophosphamide, vincristine, methotrexate, carboplatin, and etoposide) and intraventricular methotrexate. Treatment was terminated if a complete remission was achieved… CONTINUE READING
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