Treatment of dural sinus thrombosis by urokinase infusion.

  title={Treatment of dural sinus thrombosis by urokinase infusion.},
  author={Tony P. Smith and Randall Higashida and Stan L Barnwell and Van Halbach and C F Dowd and Kenneth W Fraser and George P. Teitelbaum and Grant B. Hieshima},
  journal={AJNR. American journal of neuroradiology},
  volume={15 5},
PURPOSE To gain a preliminary understanding of the role of thrombolytic therapy for the thrombosed dural sinus, we retrospectively reviewed our initial experience. METHODS Seven patients, ages 25 to 71, who presented with symptomatic dural sinus thrombosis and who failed a trial of medical therapy were treated with direct infusion of urokinase into the thrombosed sinus. Patients received urokinase doses ranging from 20,000 to 150,000 U/h with a mean infusion time of 163 hours (range 88 to 244… CONTINUE READING


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Differential effect of recombinant tissue plasminogen activator-induced thrombolysis in the central nervous system and systemic arteries

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