Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.

@article{Strupp2003TreatmentOD,
  title={Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.},
  author={Michael Strupp and Olaf Schueler and Siegbert Krafczyk and Klaus Jahn and Franz Schautzer and Ulrich B{\"u}ttner and Thomas Brandt},
  journal={Neurology},
  year={2003},
  volume={61 2},
  pages={165-70}
}
BACKGROUND Several drugs that primarily act on gamma-aminobutyrate or muscarinic receptors have been used to treat downbeat nystagmus (DBN) syndrome despite their having only moderate success and causing several side effects that limit their effectiveness. These drugs were tested under the assumption that DBN was caused by a disinhibition of a physiologic inhibitory cerebellar input on vestibular nuclei. OBJECTIVE To evaluate the effects of a single dose of the potassium channel blocker 3,4… CONTINUE READING
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