Treatment of depressive symptoms in Parkinson's disease.

  title={Treatment of depressive symptoms in Parkinson's disease.},
  author={Paolo Barone},
  journal={European journal of neurology},
  volume={18 Suppl 1},
Significant depressive disorders are present in approximately 30-40% of patients with Parkinson's disease (PD). Depressive symptoms are correlated with poor health-related quality-of-life (HRQoL) scores, and are the major determinant of HRQoL. Studies that have evaluated pharmacotherapy for depressive symptoms in PD have shown that there is substantial variability in outcomes. Recently, two double-blind, placebo-controlled studies showed the superiority of nortriptyline and desipramine versus… CONTINUE READING