Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects.

@article{Kuenzel2003TreatmentOD,
  title={Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects.},
  author={Heike E. Kuenzel and A. Zobel and Thomas Nickel and Nibal Ackl and M. Uhr and Annette Sonntag and Marcus Ising and Florian Holsboer},
  journal={Journal of psychiatric research},
  year={2003},
  volume={37 6},
  pages={525-33}
}
A dysregulation of the hypothalamus-pituitary-adrenocortical (HPA) system has been hypothesized to account for a myriad of cardinal symptoms of affective disorders. Specifically, increased CRH signalling via CRH type 1 receptors is thought to be an important factor in the pathogenesis of major depression and anxiety disorders. Consequently, a number of drugs have been developed in order to target the postulated increase in CRH/CRH 1 receptor signalling. One of these compounds, R121919, binds… CONTINUE READING

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