Treatment of chronic myeloid leukemia when imatinib fails.

Abstract

INTRODUCTION Imatinib failure represents a major clinical challenge in the management of chronic myeloid leukemia. AREAS COVERED Definition of failure, its causes, the various approaches to the treatment of imatinib failure such as imatinib dose escalation, second-generation tyrosine kinase inhibitors and stem cell transplantation, and monitoring of… (More)
DOI: 10.1517/14656566.2011.533169

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