Treatment of chronic hepatitis C infection with peginterferons plus ribavirin.

  title={Treatment of chronic hepatitis C infection with peginterferons plus ribavirin.},
  author={Michael W. Fried and Stephanos J. Hadziyannis},
  journal={Seminars in liver disease},
  volume={24 Suppl 2},
Interferon monotherapy provided the first hope for patients with chronic hepatitis C that the virus could be permanently eradicated. An important development in treating this disease was the recognition that the effects of interferon could be greatly enhanced by combining it with ribavirin, a nucleoside analogue. This combination regimen essentially doubled the sustained virological response rates seen with interferon alone. Recently, modified forms of interferon have been developed that-when… CONTINUE READING


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