Treatment of chronic hepatitis B

  title={Treatment of chronic hepatitis B},
  author={Patrick Marcellin and Tarik Asselah and Nathalie Boyer},
  journal={Nature Clinical Practice Gastroenterology &Hepatology},
In the last years, marked progress has been made in the treatment of chronic hepatitis B. The efficacy of lamivudine, the first nucleoside analogue available, is limited by the high incidence of resistance. Adefovir, which was recently approved has a comparable efficacy with a very low frequency of resistance. However, adefovir needs to be indefinitely administered as withdrawal of therapy is generally associated with reactivation and sustained response is uncommon. Recent large randomized… CONTINUE READING


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