Treatment of chronic allodynia in spinally injured rats: effects of intrathecal selective opioid receptor agonists.

@article{Hao1998TreatmentOC,
  title={Treatment of chronic allodynia in spinally injured rats: effects of intrathecal selective opioid receptor agonists.},
  author={J. X. Hao and W R Yu and Zsuzsanna Wiesenfeld-Hallin and X Jing Xu},
  journal={Pain},
  year={1998},
  volume={75 2-3},
  pages={209-17}
}
We examined the effects of intrathecal (i.t.) selective opioid receptor agonists in alleviating mechanical and cold allodynia in spinally injured rats. Both DAMGO ([D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin, a mu-opioid receptor agonist) and DPDPE ([D-Phe2,D-Phe5]-enkephalin, a delta-opioid receptor agonist) dose-dependently relieved the chronic allodynia-like behavior at doses selective for their respective receptors. The anti-allodynic effect of DAMGO and DPDPE was reversed by the selective mu… CONTINUE READING