Treatment of chronic, refractory cough with baclofen.

@article{Dicpinigaitis1998TreatmentOC,
  title={Treatment of chronic, refractory cough with baclofen.},
  author={Peter V. Dicpinigaitis and Khalid Rauf},
  journal={Respiration; international review of thoracic diseases},
  year={1998},
  volume={65 1},
  pages={86-8}
}
Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of gamma-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrated the ability of baclofen to inhibit capsaicin-induced cough, as well as cough due to angiotensin-converting enzyme (ACE) inhibitors. Herein, we… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Diagnosis and treatment of patients with nonacid gastroesophageal reflux-induced chronic cough

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences • 2015
View 1 Excerpt

Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery • 2013

Pharmacologic therapy for cough.

Current opinion in pharmacology • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…