Treatment of chronic, refractory cough with baclofen.

  title={Treatment of chronic, refractory cough with baclofen.},
  author={Peter V. Dicpinigaitis and Khalid Rauf},
  journal={Respiration; international review of thoracic diseases},
  volume={65 1},
Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of gamma-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrated the ability of baclofen to inhibit capsaicin-induced cough, as well as cough due to angiotensin-converting enzyme (ACE) inhibitors. Herein, we… CONTINUE READING

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