Treatment of childhood autoimmune haemolytic anaemia with rituximab.


Autoimmune haemolytic anaemia commonly has a severe course in young children, thus requiring multiple immunosuppressive treatments. Five children with refractory idiopathic autoimmune haemolytic anaemia, and one child with the disease after bone-marrow transplantation, were treated with rituximab-a monoclonal antibody against CD20. Tolerance of the treatment was good. However, circulating Bcells were absent and hypogammaglobulinaemia was seen for 9 months after treatment. All patients remained in complete remission 15-22 months after the start of rituximab therapy. Corticosteroids and immunosuppressive drugs were stopped or their dose markedly reduced. We suggest that rituximab could be a valuable treatment for autoimmune haemolytic anaemia, although a long-lasting but transient B-cell deficiency develops.

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@article{Quartier2001TreatmentOC, title={Treatment of childhood autoimmune haemolytic anaemia with rituximab.}, author={Pierre Quartier and Beno{\^i}t Brethon and Pierre Philippet and Judith Landman-Parker and Françoise le Deist and Alain Fischer}, journal={Lancet}, year={2001}, volume={358 9292}, pages={1511-3} }