Treatment of chemotherapy resistant ovarian cancer with a MDR1 targeted oncolytic adenovirus.


OBJECTIVE Multidrug resistance gene 1 (MDR1) mediated resistance to chemotherapeutic agents is a major obstacle for the therapy of various cancer types. The use of conditionally replicating adenoviruses (CRAds) is dependent on molecular differences between tumor cells and non tumor cells. Transcriptional targeting of CRAd replication is an effective way to… (More)
DOI: 10.1016/j.ygyno.2011.06.007


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