Treatment of cerebrospinal fluid leaks and gram-negative bacillary meningitis with large doses of intrathecal amikacin and systemic antibiotics.

@article{Gilbert1986TreatmentOC,
  title={Treatment of cerebrospinal fluid leaks and gram-negative bacillary meningitis with large doses of intrathecal amikacin and systemic antibiotics.},
  author={Villard Gilbert and Janette Beals and S E Natelson and W A Tyler},
  journal={Neurosurgery},
  year={1986},
  volume={18 4},
  pages={402-6}
}
Six patients with cerebrospinal fluid (CSF) leaks and gram-negative bacillary meningitis (GNBM) were treated with large doses of intrathecal amikacin (20 to 40 mg daily) and systemic antibiotics. Bactericidal activity was measured in the CSF of each patient, and the dose of intrathecal amikacin was increased if bactericidal activity was absent. Five of six… CONTINUE READING