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Idiopathic Late-Onset Cerebellar Ataxia with Phenytoin: A Case Report
A case of a 30-year-old male patient who had chief complaints of ataxia, giddiness and vomiting and had past medical history of epilepsy for which he was adherent to phenytoin from past four years is reported.
Comprehensive systematic review summary: Treatment of cerebellar motor dysfunction and ataxia
Evidence regarding ataxia treatment is reviewed according to American Academy of Neurology methodology and data are insufficient to support or refute the use of numerous agents.
Treatment Options in Degenerative Cerebellar Ataxia: A Systematic Review
- MedicineMovement disorders clinical practice
The etiology of cerebellar ataxia (CA) is heterogeneous and includes easily identified and often reversible causes (i.e., drug toxicity and vitamin B12 deficiency) as well as irreversible…
5-HT2A receptor-mediated excitation on cerebellar fastigial nucleus neurons and promotion of motor behaviors in rats
- Chemistry, MedicinePflügers Archiv - European Journal of Physiology
It is shown that only 5-HT2A receptors among the 5- HT2 receptor subfamily are expressed and localized in the rat cerebellar fastigial nucleus (FN), one of the ultimate outputs of the spinocerebellum precisely regulating trunk and limb movements.
Neurochemistry and Neuropharmacology of the Cerebellar Ataxias
The predominant (though not exclusive) reference to degenerative ataxias is due to the fact that the specificity of the affected cell populations should allow anticipation of more or less specific…
Treatment of spinocerebellar ataxia with buspirone
- MedicineJournal of the Neurological Sciences
Use of fluoxetine for treatment of Machado‐Joseph disease: an open‐label study
- Psychology, MedicineActa neurologica Scandinavica
Context – Machado‐Joseph Disease (MJD/SCA3) is an autosomal dominant spinocerebellar degeneration that evolves to disability and death. Experimental data have shown that serotonin is an important…
Coexistence and function of different neurotransmitter transporters in the plasma membrane of CNS neurons
- Biology, MedicineProgress in Neurobiology
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Use of buspirone for treatment of cerebellar ataxia. An open-label study.
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Nine patients with mild or moderate cerebellar dysfunction who completed the study showed significant improvement in clinical and self-assessment ratings, but not in a motor performance test, posturography, State-Trait Anxiety Inventory, and Beck Depression Inventory, suggesting buspirone may be effective in treating mild to moderate Cerebellar ataxia.
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Raphe organization of cerebellar monaminergic systems morphogenesis of serotonergic neurons serotonergic receptors in cerebellum and inferior olive neurophysiology of cerebellar serotonergic…
Improvement of cerebellar ataxia with levorotatory form of 5-hydroxytryptophan. A double-blind study with quantified data processing.
- MedicineArchives of neurology
The levorotatory form of 5-hydroxytryptophan significantly improved the ataxia score and significantly modified the time of standing upright, the spread of feet, the speed of walking, speaking, and writing.
Indoleamine neurons and their processes in the normal rat brain and in chronic diet‐induced thiamine deficiency demonstrated by uptake of 3H‐Serotonin
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Whether changes in the brains of normal, pair‐fed control, and thiamine deficient rats are disturbances in the ability of certain indoleamine neurons to take up and retain 3H‐5HT or true neuronal degeneration is unresolved.