BACKGROUND Q-Switched Nd:YAG laser (1064 nm) is a new modality that was reported to be effective in treatment of acne scars. OBJECTIVE To evaluate the effectiveness and the safety of this laser in treatment of acne scars. PATIENTS AND METHODS This case series, descriptive and comparative study was conducted in Al-Najaf Teaching Hospital of Kufa Medical College, Iraq from October 2010 to October 2011. A total of 16 patients having mild to moderate facial acne scars were enrolled; 10 of them completed the study. All patients had Fitzpatrick skin type III. They were divided into two groups A and B and were treated with two different energy fluences: 5 J/cm2 for group (A) and 15 J/cm2 for group (B). Five treatment sessions with 2-week intervals were done for all patients and were followed up for 6 months. The improvement was evaluated by objective and subjective methods. RESULTS Changes in acne scores in both groups were statistically insignificant after 6 months follow-up. Only two patients were satisfied with the improvement after treatment- one patient from each group. No serious side effects were reported. CONCLUSION Q-Switched Nd:YAG laser (1064 nm) can be used in treating atrophic facial scars of acne vulgaris.