Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin or metronidazole. A randomized, placebo-controlled trial.

@article{Johnson1992TreatmentOA,
  title={Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin or metronidazole. A randomized, placebo-controlled trial.},
  author={Sonja Elizabeth Johnson and Scott R. Homann and Kris M Bettin and John R. Quick and Connie R. Clabots and Lance R. Peterson and Dale N. Gerding},
  journal={Annals of internal medicine},
  year={1992},
  volume={117 4},
  pages={
          297-302
        }
}
OBJECTIVE To compare the efficacy of vancomycin and metronidazole for eradication of asymptomatic Clostridium difficile fecal excretion as a means of controlling nosocomial outbreaks of C. difficile diarrhea. DESIGN Randomized, placebo-controlled, non-blinded trial. SETTING Six hundred-bed regional referral Veterans Affairs Medical Center. PATIENTS Thirty patients excreting C. difficile without diarrhea or abdominal symptoms. INTERVENTIONS All patients were randomized to receive 10 days… CONTINUE READING
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