Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.

@article{Iwakoshi2000TreatmentOA,
  title={Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.},
  author={Neal N. Iwakoshi and John P Mordes and Thomas G. Markees and N E Phillips and Aldo A. Rossini and Dale L. Greiner},
  journal={Journal of immunology},
  year={2000},
  volume={164 1},
  pages={
          512-21
        }
}
A two-element protocol consisting of one donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. To study the mechanism of allograft survival, we determined the fate of tracer populations of alloreactive transgenic CD8+ T cells in a normal microenvironment. We observed that DST plus anti-CD154 mAb prolonged allograft survival and deleted alloreactive transgenic CD8+ T cells. Neither component alone did… CONTINUE READING

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