Treatment of adults with severe aplastic anemia: primary therapy with antithymocyte globulin (ATG) and rescue of ATG failures with bone marrow transplantation.

@article{Crump1992TreatmentOA,
  title={Treatment of adults with severe aplastic anemia: primary therapy with antithymocyte globulin (ATG) and rescue of ATG failures with bone marrow transplantation.},
  author={Michael R Crump and Loree M. Larratt and Eiji Maki and Joseph E. Curtis and Mark D Minden and Jacinta M. Meharchand and Jeff H. Lipton and Hans A. Messner},
  journal={The American journal of medicine},
  year={1992},
  volume={92 6},
  pages={596-602}
}
PURPOSE To evaluate a policy of immunosuppression with antithymocyte globulin (ATG) as primary therapy for adults with severe aplastic anemia (SAA) regardless of the availability of an HLA-identical bone marrow donor. PATIENTS AND METHODS Thirty-one consecutive adults with SAA who satisfied the age criteria for allogeneic bone marrow transplantation (BMT) (age less than 51 years) were treated with ATG 20 mg/kg/day for 10 days along with high-dose corticosteroids. Patients with an HLA… CONTINUE READING

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