Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy.

@article{Zhou2007TreatmentOA,
  title={Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy.},
  author={Guang-Biao Zhou and Ji Zhang and Zhen-yi Wang and Sai-juan Chen and Zhu Chen},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2007},
  volume={362 1482},
  pages={959-71}
}
To turn a disease from highly fatal to highly curable is extremely difficult, especially when the disease is a type of cancer. However, we can gain some insight into how this can be done by looking back over the 50-year history of taming acute promyelocytic leukaemia (APL). APL is the M3 type of acute myeloid leukaemia characterized by an accumulation of abnormal promyelocytes in bone marrow, a severe bleeding tendency and the presence of the chromosomal translocation t(15;17) or variants. APL… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 110 references

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.

Haematology and blood transfusion • 1989
View 5 Excerpts
Highly Influenced

( APML ) with atypical features

L. Degos
2003
View 4 Excerpts
Highly Influenced

The history of acute promyelocytic leukaemia.

British journal of haematology • 2003
View 6 Excerpts
Highly Influenced

Long - term follow - up confirms the benefit of all - trans retinoic acid ( ATRA ) and arsenic trioxide ( As 2 O 3 ) as front line therapy for newly diagnosed acute promyelocytic leukemia ( APL )

Y. F. Liu, Y. M. Zhu, +5 authors J. Hu
Blood • 2006
View 1 Excerpt

Long-term follow-up confirms the benefit of all-trans retinoic acid (ATRA) and arsenic trioxide

Y. F. Liu, Y. M. Zhu, +5 authors J. Hu
2006
View 1 Excerpt

Similar Papers

Loading similar papers…