Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital.

@article{Rivera1993TreatmentOA,
  title={Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital.},
  author={Gaston K. Rivera and Dan Pinkel and Joseph V. Simone and Michael L. Hancock and William M. Crist},
  journal={The New England journal of medicine},
  year={1993},
  volume={329 18},
  pages={1289-95}
}
BACKGROUND Therapy for childhood lymphoblastic leukemia has evolved during the past three decades, but key questions about what are the least toxic, most effective forms of treatment remain unanswered because of the lack of comprehensive follow-up information. METHODS To assess long-term outcome in the series of clinical trials conducted at St. Jude Hospital, we compared the results of treatment typical of four eras: exploratory combination chemotherapy (era 1, 1962 to 1966; 91 patients… CONTINUE READING

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