[Treatment of acute ischemic stroke with intravenous thrombolysis: extension of the time window should not delay initiation of treatment].

Abstract

In the European Cooperative Acute Stroke Study 3 (ECASS3), the efficacy of intravenous thrombolysis between 3 and 4.5 hours following onset of ischaemic stroke was investigated. Compared to the placebo group, patients treated with intravenous alteplase had a better functional outcome after 3 months (odds ratio 1.34, 95% confidence interval 1.02-1.76). The risk of symptomatic intracerebral haemorrhage was higher in the alteplase group (2.4% versus 0.3%). The time window for intravenous alteplase can be safely extended to 4.5 hours, but efforts should be made to start treatment as soon as possible, since the effectiveness ofalteplase decreases over time.

Cite this paper

@article{Uyttenboogaart2008TreatmentOA, title={[Treatment of acute ischemic stroke with intravenous thrombolysis: extension of the time window should not delay initiation of treatment].}, author={Maarten Uyttenboogaart and G . J . R . Luijckx and L J Jaap Kappelle and Robert J van Oostenbrugge and Diederik W. J. Dippel and Jan Stam}, journal={Nederlands tijdschrift voor geneeskunde}, year={2008}, volume={152 49}, pages={2653-5} }