Treatment of acute intravascular thrombi with diagnostic ultrasound and intravenous microbubbles.

@article{Xie2009TreatmentOA,
  title={Treatment of acute intravascular thrombi with diagnostic ultrasound and intravenous microbubbles.},
  author={Feng Xie and John Lof and Carr Everbach and Anming He and Richard M. Bennett and Terry Onichi Matsunaga and Jason Michael Johanning and Thomas R. Porter},
  journal={JACC. Cardiovascular imaging},
  year={2009},
  volume={2 4},
  pages={511-8}
}
The purpose of this study was to determine whether high mechanical index (MI) impulses from diagnostic ultrasound (DUS) could dissolve intravascular thrombi using intravenous microbubbles. Using a canine model, DUS was applied during a continuous intravenous infusion of microbubbles. Completely thrombosed grafts were assigned to 2 treatment regimens: low-MI (<0.5-MI) ultrasound alone; or intermittent high-MI impulses (1.9-MI) guided by low-MI ultrasound (contrast pulse sequencing). A 20-MHz… CONTINUE READING