Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes.

@article{Nguyen2005TreatmentOA,
  title={Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes.},
  author={Tuan Huy Nguyen and Gang Mai and Peter Villiger and Jos{\'e} Oberholzer and Patrick Salmon and Philippe M Morel and Leo H. B{\"u}hler and Didier Trono},
  journal={Journal of hepatology},
  year={2005},
  volume={43 6},
  pages={1031-7}
}
BACKGROUND/AIMS Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. The use of a bioartificial organ capable of fulfilling the main functions of the liver would represent an attractive alternative. However, the shortage of suitable donor cells, and their limited growth ability have impeded the development of this strategy. We investigated whether lentiviral vectors allow for conditional immortalization of human… CONTINUE READING