Treatment of Wilson's disease with triethylene tetramine hydrochloride (Trientine).

@article{Dubois1990TreatmentOW,
  title={Treatment of Wilson's disease with triethylene tetramine hydrochloride (Trientine).},
  author={Reuben S. Dubois and Denis O. Rodgerson and K Michael Hambidge},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={1990},
  volume={10 1},
  pages={
          77-81
        }
}
Penicillamine is the drug of choice for the treatment of Wilson's disease, whatever the stage of the illness. Toxic manifestations may preclude the use of this life-saving drug in some patients and discontinuation of penicillamine therapy usually leads to death. We report our experience with Trientine in seven patients, aged 13 to 33 years, with Wilson's disease who developed toxic manifestations with penicillamine that required discontinuation of therapy. These include two with nephrosis, one… CONTINUE READING

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