Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy

@article{Borody2003TreatmentOU,
  title={Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy},
  author={T. Borody and Eloise F Warren and S. Leis and R. Surace and O. Ashman},
  journal={Journal of Clinical Gastroenterology},
  year={2003},
  volume={37},
  pages={42-47}
}
Background Although the etiology of idiopathic ulcerative colitis (UC) remains poorly understood, the intestinal flora is suspected to play an important role. Specific, consistent abnormalities in flora composition peculiar to UC have not yet been described, however Clostridium difficile colitis has been cured by the infusion of human fecal flora into the colon. This approach may also be applicable to the treatment of UC on the basis of restoration of flora imbalances. Goal To observe the… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
Bacteria as the cause of ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory condition of the large bowel of unknown aetiology, characterised by the presence of bloody diarrhoea and mucus associated with a negative stoolExpand
Campylobacter colitis presentin as inflammatory bowel disease with segmental colonic ulcerations.
TLDR
Therapy with erythromycin led to prompt clinical improvement, clearance of the pathogen, and normalization of the colon by repeat examination 11 days after the initiation of the therapy. Expand
Campylobacter colitis presenting as inflammatory bowel disease with segmentai colonic ulcerations
TLDR
Therapy with erythromycin led to prompt clinical improvement, clearance of the pathogen, and normalization of the colon by repeat examination 11 days after the initiation of the therapy. Expand
Acute infective colitis caused by endemic pathogens in western Europe: endoscopic features.
TLDR
Data indicate that in the presence of an acute attack of colitis an infective etiologic agent must always be sought, and that an attack of chronic idiopathic inflammatory bowel disease may be caused by an intercurrent infection. Expand
Adhesive Escherichia coli in inflammatory bowel disease and infective diarrhoea.
TLDR
The adhesive properties of the isolates from patients with inflammatory bowel disease were similar to those of pathogenic intestinal E coli, raising the possibility that they may have a role in the pathogenesis of the condition. Expand
BACTERIOTHERAPY FOR CHRONIC RELAPSING CLOSTRIDIUM DIFFICILE DIARRHOEA IN SIX PATIENTS
Six patients with chronic relapsing diarrhoea caused by Clostridium difficile were treated with rectal instillation of homologous faeces (one patient) or a mixture of ten different facultativelyExpand
The faecal flora in ulcerative colitis.
TLDR
The increased secretion of mucin in colitis and the presence of unprotected hyaluronic acid in ulcers seem to select these organisms which are probably the cause of the high lactic-acid content of the faeces in such patients. Expand
Amebic colitis mistaken for inflammatory bowel disease.
TLDR
Because corticosteroid treatment of patients with amebic colitis may lead to undesirable complications the indirect hemagglutination test results should be obtained in patients in whom such diagnostic confusion is likely. Expand
Treatment of recurrent Clostridium difficile–associated diarrhea by administration of donated stool directly through a colonoscope
TLDR
A patient with refractory C. difficile– associated diarrhea is described that was successfully treated by Golytely lavage, followed by administration of donated stool delivered directly through a colonoscope to all segments of the colon. Expand
TREATMENT OF ULCERATIVE COLITIS BY IMPLANTATION OF NORMAL COLONIC FLORA
TLDR
The candida was fully sensitive to antifungal agents and the patient was given a single dose of fluconazole 3 mg/kg, and serum trough levels were 3-8mg/1 and 2.0 mg/1, respectively (the minimum inhibitory concentration for the strain was 0-8 mg/ 1). Expand
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