Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy

  title={Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy},
  author={Thomas J. Borody and Eloise F. Warren and Sharyn M Leis and Rosangela Surace and Ori Ashman},
  journal={Journal of Clinical Gastroenterology},
Background Although the etiology of idiopathic ulcerative colitis (UC) remains poorly understood, the intestinal flora is suspected to play an important role. Specific, consistent abnormalities in flora composition peculiar to UC have not yet been described, however Clostridium difficile colitis has been cured by the infusion of human fecal flora into the colon. This approach may also be applicable to the treatment of UC on the basis of restoration of flora imbalances. Goal To observe the… 
Medical stool: the future of treatment for inflammatory bowel disease?
Ten patients with mild to moderate ulcerative colitis who received retention fecal enemas for 5 consecutive days to treat their UC show evidence of feasibility and proof of principle for fecal transplantation in UC, but many questions remain.
Fecal Microbial Transplant Via Nasogastric Tube for Active Pediatric Ulcerative Colitis
This study, although showing that single-dose FMT via nasogastric tube is well tolerated in active pediatric UC, did not show any clinical or laboratory benefit.
Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection.
  • E. Gough, Henna Shaikh, A. Manges
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2011
Effectiveness varied by route of instillation, relationship to stool donor, volume of IMT given, and treatment before infusion, but findings can guide physicians interested in implementing the procedure until better designed studies are conducted to confirm best practices.
Successful colonoscopic fecal microbiota transplantation for active ulcerative colitis: First report from India
Colonoscopic FMT may be effective in inducing drug-free remission in patients with active UC and remains in clinical and endoscopic remission 8  Months after FMT and 2 months after withdrawal of all medication.
Fecal microbiota transplantation in ulcerative colitis.
FMT seems to be a promising and safe therapy in the management of UC, and further research will be needed to confirm this and to determine the optimal FMT procedure.
Reduced Diversity and Imbalance of Fecal Microbiota in Patients with Ulcerative Colitis
UC patients have imbalances in the intestinal environment—less diversity of fecal microbiota, lower levels of major anaerobic bacteria (Bacteroides and Clostridium subcluster XIVab), and a lower concentration of organic acids.
Fecal microbiota transplantation in refractory ulcerative colitis – a case report
Despite the FMT failure observed in this patient, the procedure is a promising therapeutic option for IBD patients, and more in-depth studies of this method are needed.
Patient Perceptions of Fecal Microbiota Transplantation for Ulcerative Colitis
Background:Fecal microbiota transplantation (FMT), the delivery of stool from a healthy prescreened donor to an individual with disease, is gaining increasing recognition as a potential treatment for
Durable Alteration of the Colonic Microbiota by the Administration of Donor Fecal Flora
This study demonstrates a durable beneficial change in the patients' bacterial populations of the colon to represent those of the healthy donor's microbiota, indicating a promising field of new therapeutic strategies for the treatment of gastrointestinal conditions.


Bacteria as the cause of ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory condition of the large bowel of unknown aetiology, characterised by the presence of bloody diarrhoea and mucus associated with a negative stool
Campylobacter colitis presentin as inflammatory bowel disease with segmental colonic ulcerations.
Therapy with erythromycin led to prompt clinical improvement, clearance of the pathogen, and normalization of the colon by repeat examination 11 days after the initiation of the therapy.
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Data indicate that in the presence of an acute attack of colitis an infective etiologic agent must always be sought, and that an attack of chronic idiopathic inflammatory bowel disease may be caused by an intercurrent infection.
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The adhesive properties of the isolates from patients with inflammatory bowel disease were similar to those of pathogenic intestinal E coli, raising the possibility that they may have a role in the pathogenesis of the condition.
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The increased secretion of mucin in colitis and the presence of unprotected hyaluronic acid in ulcers seem to select these organisms which are probably the cause of the high lactic-acid content of the faeces in such patients.
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Because corticosteroid treatment of patients with amebic colitis may lead to undesirable complications the indirect hemagglutination test results should be obtained in patients in whom such diagnostic confusion is likely.
“flora power”—fecal bacteria cure chronic C. difficile diarrhea
  • T. Borody
  • Medicine
    American Journal of Gastroenterology
  • 2000