Treatment of Tourette Syndrome with Cannabinoids

  title={Treatment of Tourette Syndrome with Cannabinoids},
  author={Kirsten R. M{\"u}ller-Vahl},
  journal={Behavioural Neurology},
  pages={119 - 124}
Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence that marijuana might be effective not only in the suppression of tics, but also in the treatment of associated behavioural problems. At the present time there are only two controlled… 

Cannabis in the Treatment of Dystonia, Dyskinesias, and Tics

Clinical research is reviewed using various formulations of cannabis (botanical products, oral preparations containing ∆9-tetrahydrocannabinol and/or cannabidiol) and currently available preparations in the USA (nabilone and dronabinol), expanded from a recent systematic review to include case reports and case series and results of anonymous surveys of patients using cannabis outside of medical settings.

Cannabinoids for the Treatment of Movement Disorders

There is growing evidence of a “cannabinoid entourage effect” in which a combination of cannabinoids derived from the plant are more effective than any single cannabinoid for a number of conditions.

The Potential of Cannabinoid-Based Treatments in Tourette Syndrome

Clinical use for refractory patients should at the very least be restricted to adult populations, given the uncertain efficacy and risk of developmental adverse effects that cannabinoids may have in children, and the overall efficacy and safety of cannabinoid-based treatments is largely unknown.

The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?

Evidence from both animal and human studies suggests that the ECS plays a role in OCD symptoms and may be a target for the development of novel medications.

Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample

This study compares the prevalence of use and dependence on cannabis in individuals with obsessive-compulsive symptomatology (OCS) with that of individuals with other psychiatric symptoms (psychosis, depression, and anxiety), and to explore the association between genetic risk and use.

The use of psychoactive substances in the treatment of mental disorders

Research on the use of psychoactive substances in mental disorder treatment has become in-creasingly important over the last 50 years. Numerous publications suggest their effectiveness in the

Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report

A female patient suffering from treatment-resistant Tourette syndrome shows a rapid and highly significant improvement in the Yale Global Tic Severity Scale, and it can be speculated whether the beneficial effects may rely on the pharmacological properties of cannabidiol.

Cannabinoids and the expanded endocannabinoid system in neurological disorders

The biology of cannabinoids, the endocannabinoid system and the expanded endoc cannabinoidoid system are outlined and the involvement in and clinical relevance of these systems and the therapeutic potential of cannabinoids across the spectrum of neurological disease are discussed.

Medical Marijuana: Just the Beginning of a Long, Strange Trip?

Physical therapists should be aware of the options that are available for patients considering medical marijuana and should be ready to provide information for these patients, and Clinicians should be vigilant for any problems that may arise if patients are using cannabinoids during physical rehabilitation.



Cannabinoids for Tourette's Syndrome.

Not enough evidence is found to support the use of cannabinoids in treating tics and obsessive compulsive behaviour in people with Tourette's syndrome.

Treatment of Tourette Syndrome with Delta-9-Tetrahydrocannabinol (Δ9-THC): No Influence on Neuropsychological Performance

Results from this study corroborate previous data suggesting that in patients suffering from TS, treatment with Δ9-THC causes neither acute nor long-term cognitive deficits.

Combined Treatment of Tourette Syndrome with Δ9-THC and Dopamine Receptor Antagonists

It is suggested for the first time that Δ9-THC may be useful in augmenting the pharmacological response to atypical NL such as amisulpride and risperidone in TS patients.

The therapeutic potential of cannabis and cannabinoids.

There is now clear evidence that cannabinoids are useful for the treatment of various medical conditions.

Treatment of Tourette's Syndrome with Δ9-Tetrahydrocannabinol (THC): A Randomized Crossover Trial

Results obtained from this pilot study suggest that a single-dose treatment with Delta(9)-THC is effective and safe in treating tics and OCB in TS.

Cannabinoids: possible role in patho‐physiology and therapy of Gilles de la Tourette syndrome

The results provide more evidence that marijuana improves tics and behavioural disorders in TS and suggest that the cannabinoid system might play a major role in TS pathology.

Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial.

The results provide more evidence that THC is effective and safe in the treatment of tics and hypothesized that the central cannabinoid receptor system might play a role in TS pathology.

Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial.

Results obtained from this pilot study suggest that a single-dose treatment with Delta(9)-THC is effective and safe in treating tics and OCB in TS.

[Gilles de la Tourette syndrome. Effect of nicotine, alcohol and marihuana on clinical symptoms].

It is suggested that marijuana influences an assumed interaction between cannabinoid and dopamine receptors and, by this, influences the dopaminergic processes in basal ganglia and motor activity in Tourette syndrome.

Nutritional supplements and complementary/alternative medicine in Tourette syndrome.

There is no evidence that use of supplements and other CAM is rarer among TS patients than in the general population, and most supplement users reported an improvement in tics.