Treatment of Temporomandibular Disorders with Botulinum Toxin

  title={Treatment of Temporomandibular Disorders with Botulinum Toxin},
  author={Marvin Schwartz and Brian J. Freund},
  journal={The Clinical Journal of Pain},
Abstract: Temporomandibular disorder (TMD) is a collective term used to characterize a heterogeneous group of conditions involving the temporomandibular joint (TMJ) and its contiguous tissues. Although the pathologies behind TMDs have not been completely explained, the symptoms associated with these disorders are similar and are most commonly manifest as pain in the orofacial region. In preliminary studies, botulinum toxin has been used successfully to treat various pain syndromes, including… 
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Diagnosis and treatment of temporomandibular disorders.


Botulinum toxin: new treatment for temporomandibular disorders.
The results strongly suggest that BTX-A reduces severity of symptoms and improves functional abilities for patients with TMD and that these extend beyond its muscle-relaxing effects.
Treatment of whiplash associated neck pain [corrected] with botulinum toxin-A: a pilot study.
BTX-A treatment of subjects with chronic WAD II neck pain resulted in a significant (p < 0.01) improvement in ROM and subjective pain compared to a placebo group, but only a trend to improvement in subjective functioning.
Comparative trial of botulinum toxin type A and methylprednisolone for the treatment of tension-type headache
  • M. Porta
  • Medicine, Psychology
    Current review of pain
  • 2000
The beneficial effects of BTX-A therapy continued to improve 60 days following injection, whereas the effects of steroid therapy at this time point began to decline and this study clearly demonstrates the effectiveness of BTx-A for the treatment of TH.
Botulinum Toxin A, Adjunctive Therapy for Refractory Headaches Associated With Pericranial Muscle Tension
Four patients with chronic, predominantly tension‐type headaches and associated pericranial muscles tension failed prolonged conventional treatment and, therefore, symptomatic areas were treated with botulinum toxin A, which alleviated myalgia and reduced the severity and frequency of migraine‐ type headaches with a concomitant reduction in subsequent medical and physical therapy interventions.
Treatment of tension-type headache with botulinum toxin: a pilot study.
The presented scheme for injections of botulinum toxin into multiple pericranial muscles is a rational basis for the design of such studies and justifies further studies of botoxinum toxin therapy in patients with tension type headache.
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BTA is significantly more effective in the treatment of ICD, with less adverse effects than trihexyphenidyl.
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It can be concluded that intramuscular injection of BTX‐A is an effective treatment for chronic tension‐type headache.
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The findings indicated that temporomandibular disorders and sick leaves were strongly associated, in agreement with earlier studies suggesting that stomatognathic disorders are one link between medicine and dentistry in health care.
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The results from the three controlled clinical trials demonstrate the safety and efficacy of BTX-B in the treatment of patients with CD, including those who are resistant toBTX-A treatment.