Treatment of Submental Fat Deposit with Cholanic Acid Intra-Adipocyte Lipolysis Compared with Liposuction Prospective Study

@article{Makkar2015TreatmentOS,
  title={Treatment of Submental Fat Deposit with Cholanic Acid Intra-Adipocyte Lipolysis Compared with Liposuction Prospective Study},
  author={Rami M. Makkar},
  journal={The American Journal of Cosmetic Surgery},
  year={2015},
  volume={32},
  pages={129 - 136}
}
  • R. Makkar
  • Published 1 September 2015
  • Medicine
  • The American Journal of Cosmetic Surgery
Introduction: Over the years, liposuction has been the standard treatment for localized fatty deposit. Lipolysis is a controversial procedure based generally on phosphatidylcholine and deoxycholate injection. The purpose of this study was to compare the efficacy of cholanic acid Aqualyx with the efficacy of liposuction in women with moderate submental fatty collection. Materials and Methods: A prospective randomized study of 30 women with moderate submental fatty collection. Half of the… 

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References

SHOWING 1-10 OF 30 REFERENCES
Injection lipolysis with phosphatidylcholine and deoxycholate.
TLDR
The study shows that injection lipolysis works in human fat tissue and the authors did various scientifically approved investigations and analyses.
Lipomas treated with subcutaneous deoxycholate injections.
The Use of Phosphatidylcholine for Correction of Localized Fat Deposits
  • P. Rittes
  • Medicine
    Aesthetic Plastic Surgery
  • 2003
TLDR
A clear improvement occurred in all, with a marked reduction of the fat deposits without recurrence over a 2-year follow-up period and no weight gain.
Reduction of unwanted submental fat with ATX-101 (deoxycholic acid), an adipocytolytic injectable treatment: results from a phase III, randomized, placebo-controlled study*
Unwanted submental fat (SMF) is aesthetically unappealing, but methods of reduction are either invasive or lack evidence for their use. An injectable approach with ATX‐101 (deoxycholic acid) is under
Comments on "Injection lipolysis with phosphatidylcholine and deoxycholate".
In a previous letter to the editor, Hasengschwandtner and Gundermann1 raised the question of sodium deoxycholate's (DC) unselective action when injected subcutaneously during nonsurgical, localized
Mesotherapy and injection lipolysis.
Cavitational adipocytolysis with a new micro-gelatinous injectable for subcutaneous adipose tissue volume reduction: ex-vivo histological findings
TLDR
Results indicate that cavitational adipocytolyses using this injectable solution combined with external medium frequency ultrasound is effective for the lysis of adipocytes.
Safety of Liposuction of the Neck Using Tumescent Local Anesthesia: Experience in 320 Cases
  • B. Roland
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2012
TLDR
Liposuction of the neck with tumescent local anesthesia requires a higher amount of patient monitoring than liposuctions of the body and in the hands of an experienced surgeon, it is a safe method rendering excellent aesthetic results.
Detergent Effects of Sodium Deoxycholate Are a Major Feature of an Injectable Phosphatidylcholine Formulation Used for Localized Fat Dissolution
TLDR
The phosphatidylcholine formula popularly used in subcutaneous injections for fat dissolution works primarily as a detergent causing nonspecific lysis of cell membranes, suggesting a role in eliminating unwanted adipose tissue.
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