Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation.

@article{Vanderford2012TreatmentOS,
  title={Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation.},
  author={Thomas H. Vanderford and Chloe K. Slichter and Kenneth A Rogers and Benton O. Lawson and Rend Obaede and James G. Else and Francois Villinger and Steven E Bosinger and Guido Silvestri},
  journal={Blood},
  year={2012},
  volume={119 24},
  pages={5750-7}
}
A key feature differentiating nonpathogenic SIV infection of sooty mangabeys (SMs) from pathogenic HIV/SIV infections is the rapid resolution of type I IFN (IFN-I) responses and IFN-stimulated gene expression during the acute-to-chronic phase transition and the establishment of an immune quiescent state that persists throughout the chronic infection. We hypothesized that low levels of IFN-I signaling may help to prevent chronic immune activation and disease progression in SIV-infected SMs. To… CONTINUE READING
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