Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

@article{Vanitallie2005TreatmentOP,
  title={Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study},
  author={T. Vanitallie and C. Nonas and A. Di Rocco and K. Boyar and K. Hyams and S. Heymsfield},
  journal={Neurology},
  year={2005},
  volume={64},
  pages={728 - 730}
}
Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). [...] Key Result Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.Expand
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Paper Mentions

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Interventional Clinical Trial
Parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. Ketogenic diet has been largely studied as treatment on drug… Expand
ConditionsParkinson Disease
InterventionOther
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References

SHOWING 1-10 OF 17 REFERENCES
Ketones: metabolism's ugly duckling.
  • 129
  • PDF
The ketogenic diet: 1997.
  • 213
Body Weight Influences Pharmacokinetics of Levodopa in Parkinson's Disease
  • 69
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.
  • 351
  • PDF
Ketone Bodies, Potential Therapeutic Uses
  • 326
  • PDF
Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.
  • 59
  • PDF
Placebo‐associated improvements in motor function: Comparison of subjective and objective sections of the UPDRS in early Parkinson's disease
  • 116
...
1
2
...