Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene.

@article{Li2007TreatmentOP,
  title={Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene.},
  author={Qing-Jun Li and Ya-mei Tang and Jun Liu and Dao-You Zhou and Xiang-pen Li and Song-hua Xiao and Dong-Xing Jian and Y S Xing},
  journal={Synapse},
  year={2007},
  volume={61 12},
  pages={971-7}
}
To study the potential benefit of the NURR1 gene in Parkinson's disease (PD), we constructed a recombinant republic-deficit adenovirus containing the NURR1 gene (Ad-NURR1) and expressed it in transplanted neural stem cells (NSC). Ad-NURR1 was constructed, and NURR1 mRNA and protein expression were identified by in situ hybridization and western blot analysis, respectively. The identified NURR1 protein could directly or indirectly induce NSC differentiation into neurons. To identify a potential… CONTINUE READING

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