Treatment of Parkinson disease: a 64-year-old man with motor complications of advanced Parkinson disease.

@article{Tarsy2012TreatmentOP,
  title={Treatment of Parkinson disease: a 64-year-old man with motor complications of advanced Parkinson disease.},
  author={Daniel Tarsy},
  journal={JAMA},
  year={2012},
  volume={307 21},
  pages={2305-14}
}
In early stages, Parkinson disease typically begins with asymmetric or unilateral motor symptoms due to combinations of mild bradykinesia, rigidity, and tremor. In most cases, with progression, signs of more generalized bradykinesia appear, which include facial masking, reduced voice volume, and slowing of activities of daily living. In more advanced Parkinson disease, other disabling manifestations may follow, such as impaired balance, gait freezing, falls, speech disturbance, and cognitive… CONTINUE READING
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