Treatment of Parkinson's disease using cell transplantation.

@article{Lindvall2015TreatmentOP,
  title={Treatment of Parkinson's disease using cell transplantation.},
  author={Olle Lindvall},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2015},
  volume={370 1680},
  pages={20140370}
}
The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wide variation in functional outcome. Stem cells and reprogrammed cells could potentially be used to… CONTINUE READING
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References

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Showing 1-10 of 59 references

A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s disease

CW Olanow
Ann. Neurol • 2003
View 5 Excerpts
Highly Influenced

Human ESCderived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson ’ s disease

S Grealish
Cell Stem Cell • 2014

Long - term clinical outcome of fetal cell transplantation for Parkinson disease : two case reports

Z Kefalopoulou
JAMA Neurol . • 2014

Developing dopaminergic cell therapy for Parkinson's disease--give up or move forward?

Movement disorders : official journal of the Movement Disorder Society • 2013
View 3 Excerpts

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