Treatment of Pain Syndromes with Venlafaxine

@article{Grothe2004TreatmentOP,
  title={Treatment of Pain Syndromes with Venlafaxine},
  author={Dale R. Grothe and Brian Scheckner and Dominick Albano},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2004},
  volume={24}
}
Major depressive disorder (MDD) and anxiety disorders such as generalized anxiety disorder (GAD) are often accompanied by chronic painful symptoms. Examples of such symptoms are backache, headache, gastrointestinal pain, and joint pain. In addition, pain generally not associated with major depression or an anxiety disorder, such as peripheral neuropathic pain (e.g., diabetic neuropathy and postherpetic neuralgia), cancer pain, and fibromyalgia, can be challenging for primary care providers to… 
Antidepressant Agents for the Treatment of Chronic Pain and Depression
TLDR
Duloxetine and venlafaxine, which are serotonin and norepinephrine reuptake inhibitors, were shown in clinical trials to alleviate pain and depressive symptoms, and remain fundamental therapeutic agents for depression and anxiety disorders.
Antidepressants and Cognitive-Behavioral Therapy for Symptom Syndromes
TLDR
For the 11 painful syndromes review in this article, cognitive-behavioral therapy is most consistently demonstrated to be effective, with various antidepressants having more or less randomized controlled data supporting or refuting effectiveness.
Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews.
Comorbid Pain, Depression, and Anxiety: Multifaceted Pathology Allows for Multifaceted Treatment
TLDR
The pathophysiology of comorbid pain, anxiety, and depression is reviewed, along with the treatment modalities (pharmacologic, psychotherapeutic, and “alternative”) that may benefit all three conditions.
Adjunctive pharmacological management of persistent, nonmalignant pain in older individuals
TLDR
Oral antiepileptic drugs, mexiletine, baclofen, tricyclic antidepressants, selective serotonin–norepinephrine dual reuptake inhibitors and intranasal/injectable calcitonin are the subjects of this review of the management of persistent, nonmalignant pain in the elderly.
Pharmacologic Management of Chronic Pain
TLDR
It is essential to have a thorough understanding about the different pain mechanisms of chronic pain and evidence-based multi-mechanistic treatment and to increase the individualization of treatment.
Pharmacological Management of Mood and Anxiety Disorders in Headache Patients
TLDR
Treating comorbid psychiatric disorders in headache patients requires patient education about the psychiatric disorder, its treatment, possible side‐effects, and expected benefits, and Clinicians need to be sensitive to possible stigma that some patients fear from a psychiatric diagnosis or its treatment.
Il ruolo della Venlafaxina nella terapia della depressione unipolare con manifestazioni di dolore somatico Role of Venlafaxine in the treatment of unipolar depression associated with painful somatic symptoms
TLDR
It has been suggested that the class of serotonin and norepinephrine reuptake inhibitors (SNRI), which includes Venlafaxine, may be useful in relieving not only psychological symptoms but also chronic pain associated with unipolar depression.
Adjuvant analgesics.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 70 REFERENCES
Antidepressants in the Management of Chronic Pain Syndromes
TLDR
Antidepressants provide analgesia in conditions in which they have been used, and doses of heterocyclic antidepressants used for analgesia seem to be lower than those considered effective in the treatment of depression.
Treatment of Neuropathic Pain with Venlafaxine
TLDR
This report describes the efficacious use of venlafaxine in the treatment of neuropathic pain and suggests that double-blind, randomized, controlled trials are needed to explore this further.
Efficacy of Venlafaxine for the Long Term Treatment of Chronic Pain With Associated Major Depressive Disorder
TLDR
These data show long-term efficacy and effectiveness of venlafaxine XR, a serotonin (5-HT) and norepinephrine (NE) and dopamine (DA) reuptake inhibitor antidepressant agent, having analgesic properties.
The management challenges of chronic pain: the role of antidepressants.
TLDR
Venlafaxine, the first agent in the new class of serotonin (5-HT)-norepinephrine (NE) reuptake inhibitors, is unique because it inhibits reuptakes of both 5-HT and NE, as do some of the TCAs; however, it accomplishes this without affecting other nontherapeutic receptors.
Chronic Pain, Chronic Stress and Depression: Coincidence or Consequence?
TLDR
The possible involvement of the HPA axis in the aetiology of both chronic pain and clinical depression is discussed, and a strategy for the development of novel pharmacotherapies is suggested.
Venlafaxine in neuropathic pain following treatment of breast cancer
TLDR
The average daily pain intensity was not significantly reduced and the average pain relief and the maximum pain intensity were significantly lower with venlafaxine compared with placebo, suggesting higher doses could be used in order to improve pain relief.
Using chronic pain to predict depressive morbidity in the general population.
TLDR
The presence of CPPCs increases the duration of depressive mood and patients seeking consultation for a CPPC should be systematically evaluated for depression.
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
TLDR
Desipramine relieves pain caused by diabetic neuropathy with efficacy similar to that of amitriptyline, offering an alternative for patients unable to tolerate the latter and blockade of norepinephrine reuptake is likely to mediate the analgesic effect of these antidepressant drugs in diabetic Neuropathy.
Venlafaxine versus imipramine in painful polyneuropathy
TLDR
Venlafaxine relieves pain in polyneuropathy and may be as effective as imipramine.
...
1
2
3
4
5
...