Treatment of Pain Syndromes with Venlafaxine
@article{Grothe2004TreatmentOP, title={Treatment of Pain Syndromes with Venlafaxine}, author={Dale R. Grothe and Brian Scheckner and Dominick Albano}, journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy}, year={2004}, volume={24} }
Major depressive disorder (MDD) and anxiety disorders such as generalized anxiety disorder (GAD) are often accompanied by chronic painful symptoms. Examples of such symptoms are backache, headache, gastrointestinal pain, and joint pain. In addition, pain generally not associated with major depression or an anxiety disorder, such as peripheral neuropathic pain (e.g., diabetic neuropathy and postherpetic neuralgia), cancer pain, and fibromyalgia, can be challenging for primary care providers to…
87 Citations
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Il ruolo della Venlafaxina nella terapia della depressione unipolare con manifestazioni di dolore somatico Role of Venlafaxine in the treatment of unipolar depression associated with painful somatic symptoms
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It has been suggested that the class of serotonin and norepinephrine reuptake inhibitors (SNRI), which includes Venlafaxine, may be useful in relieving not only psychological symptoms but also chronic pain associated with unipolar depression.
References
SHOWING 1-10 OF 70 REFERENCES
Antidepressants in the Management of Chronic Pain Syndromes
- Medicine, PsychologyPharmacotherapy
- 1990
Antidepressants provide analgesia in conditions in which they have been used, and doses of heterocyclic antidepressants used for analgesia seem to be lower than those considered effective in the treatment of depression.
Treatment of Neuropathic Pain with Venlafaxine
- Medicine, PsychologyThe Annals of pharmacotherapy
- 2001
This report describes the efficacious use of venlafaxine in the treatment of neuropathic pain and suggests that double-blind, randomized, controlled trials are needed to explore this further.
Efficacy of Venlafaxine for the Long Term Treatment of Chronic Pain With Associated Major Depressive Disorder
- Psychology, MedicineAmerican journal of therapeutics
- 2003
These data show long-term efficacy and effectiveness of venlafaxine XR, a serotonin (5-HT) and norepinephrine (NE) and dopamine (DA) reuptake inhibitor antidepressant agent, having analgesic properties.
The management challenges of chronic pain: the role of antidepressants.
- Medicine, PsychologyAmerican journal of therapeutics
- 2000
Venlafaxine, the first agent in the new class of serotonin (5-HT)-norepinephrine (NE) reuptake inhibitors, is unique because it inhibits reuptakes of both 5-HT and NE, as do some of the TCAs; however, it accomplishes this without affecting other nontherapeutic receptors.
Chronic Pain, Chronic Stress and Depression: Coincidence or Consequence?
- Psychology, BiologyJournal of neuroendocrinology
- 2001
The possible involvement of the HPA axis in the aetiology of both chronic pain and clinical depression is discussed, and a strategy for the development of novel pharmacotherapies is suggested.
Venlafaxine in neuropathic pain following treatment of breast cancer
- MedicineEuropean journal of pain
- 2002
The average daily pain intensity was not significantly reduced and the average pain relief and the maximum pain intensity were significantly lower with venlafaxine compared with placebo, suggesting higher doses could be used in order to improve pain relief.
Using chronic pain to predict depressive morbidity in the general population.
- Medicine, PsychologyArchives of general psychiatry
- 2003
The presence of CPPCs increases the duration of depressive mood and patients seeking consultation for a CPPC should be systematically evaluated for depression.
Chronic pain and depression. II. Symptoms of anxiety in chronic low back pain patients and their relationship to subtypes of depression
- Psychology, MedicinePain
- 1985
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
- Medicine, PsychologyThe New England journal of medicine
- 1992
Desipramine relieves pain caused by diabetic neuropathy with efficacy similar to that of amitriptyline, offering an alternative for patients unable to tolerate the latter and blockade of norepinephrine reuptake is likely to mediate the analgesic effect of these antidepressant drugs in diabetic Neuropathy.
Venlafaxine versus imipramine in painful polyneuropathy
- Medicine, PsychologyNeurology
- 2003
Venlafaxine relieves pain in polyneuropathy and may be as effective as imipramine.