Treatment of Paget's disease of bone with aminohydroxybutylidene bisphosphonate.

  title={Treatment of Paget's disease of bone with aminohydroxybutylidene bisphosphonate.},
  author={D P O'Doherty and Derek R Bickerstaff and Eugene V. McCloskey and N A Hamdy and M. N. C. Beneton and Sean Harris and Maurizio Mian and J. A. Kanis},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={5 5},
This study examined the effects of aminohydroxybutylidene bisphosphonate in 30 patients with Paget's disease of bone, administered as an intravenous infusion for 5 consecutive days. Treatment (5 mg IV daily) induced marked suppression of biochemical indices of disease activity. Urinary excretion of hydroxyproline fell to 50% of pretreatment values within 2 weeks and was followed by a similar, but later, decline in the serum activity of alkaline phosphatase. Disease activity remained suppressed… CONTINUE READING


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