Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease

@article{Zis2019TreatmentON,
  title={Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease},
  author={Panagiotis Zis and Marios Hadjivassiliou},
  journal={Current Treatment Options in Neurology},
  year={2019},
  volume={21},
  pages={1-10}
}
Purpose of reviewThe aim of this paper was to overview the current literature in order to establish the available treatment options for the neurological manifestations of gluten-related disorders (serologically confirmed gluten sensitivity and coeliac disease).Recent findingsA range of debilitating neurological manifestations is increasingly being recognized in patients with gluten sensitivity with and without enteropathy even in the absence of gastrointestinal symptoms. Ataxia is the commonest… 
View on Springer
link.springer.com
17 Citations
Background Citations
4

Tables from this paper

17 Citations

Citation Type

Citation Type

Neurological manifestation of coeliac disease with particular emphasis on gluten ataxia and immunological injury: a review article
TLDR
This review will touch on the salient features of CD and the nervous system and will highlight current controversies in relation to gluten and GA.
Gluten neuropathy: prevalence of neuropathic pain and the role of gluten-free diet
TLDR
Strict gluten-free diet might be protective as it is associated with a significant reduction of the odds of peripheral neuropathic pain associated to GN, and is related with poorer mental health status.
Movement disorders in systemic autoimmune diseases: Clinical spectrum, ancillary investigations, pathophysiological considerations.
Coeliac disease and noncoeliac wheat or gluten sensitivity
TLDR
It is unclear which components of wheat are responsible for symptom generation in noncoeliac wheat or gluten sensitivity, with further research required to elucidate the pathophysiology.
Coeliac disease presenting with chorea
TLDR
A patient with rapidly progressive generalised chorea, but without preceding gastrointestinal symptoms, who was subsequently diagnosed with coeliac disease was reported, and a gluten-free diet resulted in complete resolution of the chorea.
General Health, Systemic Diseases and Oral Status in Adult Patients with Coeliac Disease
TLDR
Major associations were observed in caries prevalence and dentin sensitivity; in addition, an inappropriate diet was related to oral manifestations; following a gluten-free diet could be important to control the gingival bleeding levels and to manage oral symptoms associated to coeliac disease.
Living with Gluten and Other Food Intolerances: Self-Reported Diagnoses and Management
TLDR
Close to one third of the population report suffering from some FI, and those perceiving themselves as gluten intolerant report more diseases (p < 0.0001), suggesting that some celiac patients do not acknowledge it as treatment.
Successful dietary treatment of aggression and behavioral changes in a dog
The effect of sodium channels on neurological/neuronal disorders: A systematic review
TLDR
A review of the link between VGSCs and neurological and neuronal diseases was conducted and novel therapeutic targets were introduced for future drug discoveries.
Unravelling neurological disorders through metallomics-based approaches.
TLDR
A critical review presents recent advances in metallomics studies associated with neurological disorders, showing possible mechanisms involving the disruption of metal homeostasis and the pathogenesis of neurological disorders.
...
1
2
...

References

SHOWING 1-10 OF 50 REFERENCES
Movement Disorders Related to Gluten Sensitivity: A Systematic Review
TLDR
This review highlights that the phenomenology of gluten related MDs is broader than GA and demonstrates that gluten-free diet (GFD) is beneficial in a great percentage of such cases.
Neurological Dysfunction in Coeliac Disease and Non-Coeliac Gluten Sensitivity
TLDR
The neurological manifestations of CD and NCGS are similar and equally responsive to a GFD suggestive of common pathophysiological mechanisms.
Does cryptic gluten sensitivity play a part in neurological illness?
Myopathy associated with gluten sensitivity
TLDR
The experience with 13 patients who presented with symptoms and signs suggestive of a myopathy and in whom investigation led to the diagnosis of gluten sensitivity shows clinical improvement of the myopathy with a gluten‐free diet.
Gluten sensitivity and epilepsy: a systematic review
TLDR
Patients with epilepsy of unknown aetiology should be investigated for serological markers of gluten sensitivity as such patients may benefit from a GFD, according to the data.
Progressive myoclonic ataxia associated with coeliac disease. The myoclonus is of cortical origin, but the pathology is in the cerebellum.
TLDR
The neurological syndrome was dominated by action and stimulus sensitive myoclonus of cortical origin with mild ataxia and infrequent seizures and coeliac disease should be considered in the differential diagnosis of all patients presenting with a progressive myoclonic ataxic syndrome.
Transglutaminase 6 antibodies in gluten neuropathy.
  • P. Zis, D. G. Rao, M. Hadjivassiliou
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2017
Autonomic neuropathy and coeliac disease
TLDR
The frequency of coeliac disease is similar to that reported in idiopathic peripheral neuropathy, with four patients who presented subacutely with presyncope and postural nausea.
Myoclonus ataxia and refractory coeliac disease
TLDR
Detailed electro-clinical characteristics of a new syndrome of progressive cortical hyperexcitability with ataxia and refractory CD are presented, which may well be the commonest neurological manifestation of refractor CD.
Epilepsy in coeliac disease: not just a matter of calcifications
TLDR
The clinical, neuroradiological and neurophysiological features of eight consecutive epileptic patients with a diagnosis of CD confirmed by laboratory tests and duodenal biopsy are described, suggesting more complex pathogenic mechanisms may be involved in the association between epilepsy and CD.
...
1
2
3
4
5
...