Treatment of Neurodegeneration: Integrating Photobiomodulation and Neurofeedback in Alzheimer's Dementia and Parkinson's: A Review.

@article{Berman2019TreatmentON,
  title={Treatment of Neurodegeneration: Integrating Photobiomodulation and Neurofeedback in Alzheimer's Dementia and Parkinson's: A Review.},
  author={Marvin H. Berman and Trent W. Nichols},
  journal={Photobiomodulation, photomedicine, and laser surgery},
  year={2019},
  volume={37 10},
  pages={
          623-634
        }
}
  • M. Berman, T. Nichols
  • Published 2019
  • Medicine
  • Photobiomodulation, photomedicine, and laser surgery
Objective: A review of photobiomodulation (PBM) in Alzheimer's dementia is submitted. The addition of PBM in neurodegenerative diseases is a dual modality that is at present gaining traction as it is safe, antiviral, and anti-inflammatory for treating neurodegeneration with photons that stimulate mitochondria increasing adenosine triphosphate and proteasomes increasing misfolded protein removal. Neurofeedback provides neural plasticity with an increase in brain-derived nerve factor mRNA and an… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
TLDR
Novel antioxidants have shown great potential in mediating disease phenotypes and could be an area of interest for further research, as well as a highlight on the antioxidant-based therapies for alleviating disease severity. Expand
Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition.
TLDR
A small pilot double blind, placebo-controlled trial assessing the effect of 28 consecutive, sixminute transcranial sessions of near infrared (NIR) stimulation using 1060-1080 nm light emitting diodes on executive functioning and EEG amplitude and connectivity measures showed changes in executive functioning. Expand
Photobiomodulation with near infrared light mitigates Alzheimer’s disease-related pathology in cerebral cortex – evidence from two transgenic mouse models
TLDR
The results suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations. Expand
Hyperphosphorylation of Tau Protein in DownâÂÂs Dementia andAlzheimerâÂÂs Disease: Methylation and Implications in Prevention andTherapy
The changes of insulin signaling, calcium signaling, mitochondrial decline and oxidative stress have been implicated in the hyperphosphorylation of tau protein found in Downs syndrome dementia. SuchExpand
Near infrared light decreases synaptic vulnerability to amyloid beta oligomers
TLDR
Evidence is provided that NIR light can effectively reduce synaptic vulnerability to damaging Aβ oligomers, thus furthering NIRLight therapy as a viable treatment for AD. Expand
Non-invasive infra-red therapy (1072 nm) reduces β-amyloid protein levels in the brain of an Alzheimer's disease mouse model, TASTPM.
TLDR
IR1072 treatment provides a novel non-invasive and safe way to upregulate a panel of stress response proteins in the brain, known to both reduce protein aggregation and neuronal apoptosis, and may provide a novel disease modifying therapy for a range of neuropathologies. Expand
Shining light on the head: Photobiomodulation for brain disorders
TLDR
The mechanisms of action of photobiomodulation to the brain are covered, some of the key pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders are summarized, and the possibility that PBM could be used for cognitive enhancement in normal healthy people is summarized. Expand
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
TLDR
The paradigm shift that repositioned the UPS from being a prime suspect in the pathophysiology of neurodegeneration to an attractive therapeutic target that can be harnessed to accelerate the clearance of disease-linked proteins is discussed. Expand
Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease
This review focuses on research in the areas of epidemiology, neuropathology, molecular biology and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative agent in theExpand
The Epigenetics of Alzheimer’s Disease: Factors and Therapeutic Implications
TLDR
The general conclusion is that epigenetic mechanisms play a variety of crucial roles in the development of AD, and there are a number of viable possibilities for treatments based on modulating these effects, but significant advances in knowledge and technology will be needed to move these treatments from the bench to the bedside. Expand
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