Treatment of Mycobacterium avium-intracellulare complex infection in beige mice with free and liposome-encapsulated streptomycin: role of liposome type and duration of treatment.

@article{Dzgne1991TreatmentOM,
  title={Treatment of Mycobacterium avium-intracellulare complex infection in beige mice with free and liposome-encapsulated streptomycin: role of liposome type and duration of treatment.},
  author={Nejat D{\"u}zg{\"u}neş and D R Ashtekar and Diana L Flasher and Nafisa Ghori and Robert J. Debs and Daniel Friend and Pattisapu R J Gangadharam},
  journal={The Journal of infectious diseases},
  year={1991},
  volume={164 1},
  pages={143-51}
}
Current treatments for Mycobacterium avium-intracellulare complex (MAC) infections are generally ineffective. Thus, the potential of free or liposome-encapsulated streptomycin to treat acute MAC infection was investigated in beige mice. Free streptomycin administered intramuscularly 5 days a week (150 mg/kg) was effective in the liver, spleen, and lungs. At 4 weeks, liposome-encapsulated streptomycin, administered intravenously in weekly doses (15 mg/kg), reduced the colony-forming units in the… CONTINUE READING

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